Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | Set_03_truncNotch_versus_normalThy.phenotype_truncNotch_versus_normalThy.cls #truncNotch_versus_normalThy.phenotype_truncNotch_versus_normalThy.cls #truncNotch_versus_normalThy_repos |
| Phenotype | phenotype_truncNotch_versus_normalThy.cls#truncNotch_versus_normalThy_repos |
| Upregulated in class | truncNotch |
| GeneSet | HUMANCYC_SUPERPATHWAY OF HISTIDINE, PURINE, AND PYRIMIDINE BIOSYNTHESIS |
| Enrichment Score (ES) | 0.7463756 |
| Normalized Enrichment Score (NES) | 1.5949954 |
| Nominal p-value | 0.0053003533 |
| FDR q-value | 0.06472001 |
| FWER p-Value | 0.75 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | GUK1 | 5900059 | 32 | 8.897 | 0.0960 | Yes | ||
| 2 | NME2 | 2190672 | 50 | 8.197 | 0.1850 | Yes | ||
| 3 | CAD | 2340717 | 51 | 8.137 | 0.2744 | Yes | ||
| 4 | ADSL | 5570484 | 223 | 5.722 | 0.3280 | Yes | ||
| 5 | DHODH | 3170072 | 278 | 5.332 | 0.3836 | Yes | ||
| 6 | IMPDH2 | 5220138 | 292 | 5.237 | 0.4404 | Yes | ||
| 7 | GART | 5910114 7000594 | 314 | 5.102 | 0.4953 | Yes | ||
| 8 | PRPSAP1 | 6980494 | 344 | 4.933 | 0.5479 | Yes | ||
| 9 | CTPS | 70451 1740132 | 540 | 4.258 | 0.5842 | Yes | ||
| 10 | UMPS | 2340541 4730438 | 621 | 3.938 | 0.6231 | Yes | ||
| 11 | PPAT | 1980019 | 630 | 3.927 | 0.6658 | Yes | ||
| 12 | NME4 | 3140736 5900446 | 717 | 3.684 | 0.7016 | Yes | ||
| 13 | NME6 | 510136 6380722 | 828 | 3.380 | 0.7328 | Yes | ||
| 14 | NME1 | 770014 | 1145 | 2.786 | 0.7464 | Yes | ||
| 15 | GMPS | 460670 | 2055 | 1.658 | 0.7157 | No | ||
| 16 | PAICS | 610142 | 2378 | 1.343 | 0.7131 | No | ||
| 17 | AK3L1 | 7100601 | 2414 | 1.295 | 0.7254 | No | ||
| 18 | IMPDH1 | 3190735 7050546 | 2698 | 1.052 | 0.7217 | No | ||
| 19 | AK2 | 4590458 4760195 6110097 | 3006 | 0.878 | 0.7149 | No | ||
| 20 | PRPSAP2 | 60242 6590239 | 3376 | 0.656 | 0.7022 | No | ||
| 21 | AK5 | 6290348 | 3679 | 0.532 | 0.6918 | No | ||
| 22 | RRM1 | 4150433 | 3904 | 0.461 | 0.6848 | No | ||
| 23 | NME7 | 60170 1230551 2850333 4200102 4560411 5090647 | 4568 | 0.305 | 0.6525 | No | ||
| 24 | RRM2B | 1690025 1690465 4010400 | 5133 | 0.222 | 0.6245 | No | ||
| 25 | RRM2 | 6350059 6940162 | 5949 | 0.140 | 0.5822 | No | ||
| 26 | AK1 | 130605 | 6066 | 0.132 | 0.5774 | No | ||
| 27 | PURA | 3870156 | 9894 | 0.017 | 0.3717 | No | ||
| 28 | CTPS2 | 360647 3940110 | 14428 | -0.165 | 0.1296 | No | ||
| 29 | ADSSL1 | 4850132 7000288 | 14445 | -0.167 | 0.1306 | No | ||
| 30 | PRPS1 | 6350129 | 14534 | -0.186 | 0.1279 | No | ||
| 31 | KIF13B | 2480451 3830368 | 15969 | -0.788 | 0.0594 | No | ||
| 32 | ATIC | 4010593 6380463 | 17351 | -2.191 | 0.0091 | No | ||
| 33 | NME3 | 1660440 | 18392 | -5.365 | 0.0121 | No |
